Clinical Research Studies
Phase II Randomized Study of Physiologic Testosterone Replacement in Premenopausal, HIV-Positive Women Conditions: HIV Infections; Cachexia Intervention: Drug: testosterone Measurement of Outcome of Surgical Treatment in Patients With Acromegaly Condition: Acromegaly Intervention: Stachybotrys Induced Hemorrhage in the Developing Lung Condition: Idiopathic Pulmonary Hemorrhage Intervention: Human Epilepsy Genetics--Neuronal Migration Disorders Study Conditions: Epilepsy; Seizures; Cognition Disorders; Neuronal Migration Disorders Intervention: Radiotherapy Versus Radiotherapy Plus Chemotherapy in Early Stage Follicular Lymphoma Condition: Follicular Lymphoma Interventions: Drug: Cyclophosphamide; Radiation: Radiotherapy; Drug: Vincristine; Drug: Prednisolone; Drug: Rituximab Familial Amyotrophic Lateral Sclerosis (FALS) Study Condition: Amyotrophic Lateral Sclerosis Intervention: Clinical Trial of Consolidation Treatment With Iodine I 131 Tositumomab for Multiple Myeloma Condition: Multiple Myeloma Intervention: Drug: Iodine I 131 Tositumomab California WISEWOMAN Project Conditions: Cardiovascular Diseases; Chronic Diseases Intervention: Behavioral: Women's health The Effects of Maternal Nutrition During Pregnancy and Breast Feeding on the Risk of Allergic Disease in Child Conditions: Atopic Eczema; Rhinitis; Asthma Interventions: Behavioral: Dietary counselling and products with favourable fat content; Dietary Supplement: Placebo capsules MRS and DTI of White Matter in Alzheimer's Disease Conditions: Alzheimer's Disease; Vascular Dementia Intervention: Insulin Action in Individuals With Type 2 Diabetes by Natural Fatty Acids or the Medication Pioglitazone Condition: Type 2 Diabetes Mellitus Intervention: Drug: Pioglitazone/EPA Efficacy of Modified Ketogenic Diet (Atkins) in Management of Epilepsy Condition: Epilepsy Interventions: Behavioral: atkins diet; Behavioral: ability to follow low carbohydrate diet A Clinical Double Blind, Randomized Study of the Efficacy of Hyperuricemia Treatment With Anserine Product. Condition: "Hyperuricemia,Anserine" Intervention: Drug: Marine active Brief Intervention to Reduce STDs in ER Drug Users - 1 Conditions: Substance-Related Disorders; Sexual Risk Behaviors Intervention: Behavioral: Motivational interviewing Pompe Disease Registry Conditions: Glycogen Storage Disease Type II; Pompe Disease Intervention: A Strategy of Home Telehealth for Management of Congestive Heart Failure(STARTEL) Condition: Heart Failure Intervention: Device: Routine Care in a HF clinic vs Home Telehealth Care for HF Fondaparinux as an Anticoagulant in Haemofiltration in Patients With Acute Kidney Failure. Condition: Patients Requiring Haemofiltration for Acute Renal Failure. Intervention: Drug: Fondaparinux Sodium Improving Glycemic Control on GMS: A Quality Improvement Study Condition: Diabetes Mellitus Intervention: Behavioral: Order Set, Education, Feedback The Importance of Glucagon-Like Peptide-2 (GLP-2)in Mesenteric Bloodflow in Humans Condition: Healthy Intervention: Drug: GLP-2 Effectiveness of Auto-adjusted Continuous Positive Airway Pressure for Long-term Treatment of Sleep Apnea Condition: Sleep Apnea, Obstructive Interventions: Device: constant CPAP devices; Device: automatic CPAP devices
Treatment of Subarachnoid Hemorrhage With Human Albumin Condition: Subarachnoid Hemorrhage Intervention: Drug: human albumin Treatment of Non-Dislocated Midshaft Both-Bone Fractures Condition: Fracture Intervention: Device: above and below elbow cast Depakote Extended Release (ER) Versus Seroquel for Agitated Behaviors in Nursing Home Care Unit Patients With Dementia Conditions: Agitation; Dementia Interventions: Drug: Depakote ER; Drug: Seroquel Measurement of Stress During Anesthesia With ”Pain Detector” on Patients Receiving Atropine Conditions: Hemorrhoids; Fissure in Ano Interventions: Drug: Administration of 0,7 mg of atropine; Device: Measurement of skin conductance with Pain detector Arterial Stiffness and Calcifications in Haemodialysis Patients on Sevelamer or Calcium Acetate Conditions: Haemodialyzed Patients; Hyperphosphatemia Interventions: Drug: Calcium acetate; Drug: Sevelamer AFP464 in Treating Patients With Advanced Solid Tumors Condition: Unspecified Adult Solid Tumor, Protocol Specific Interventions: Drug: AFP464; Other: pharmacological study Effect of an Oral Supplement on the Total Energy and Protein Intake of Head and Neck Cancer Patients in the Last 2 Weeks of Radiation Therapy Condition: Head and Neck Cancer Intervention: Dietary Supplement: Nutritional Supplement Lymphedema Prophylaxis in Breast Cancer Survivors Who Show Early Evidence of High-risk Status Conditions: Lymphedema; Breast Cancer Intervention: Device: Flexitouch Decitabine and Tretinoin in Treating Patients With Myelodysplastic Syndromes Condition: Myelodysplastic Syndromes Interventions: Drug: decitabine; Drug: tretinoin; Genetic: DNA methylation analysis; Genetic: cytogenetic analysis; Genetic: microarray analysis; Other: flow cytometry; Other: immunohistochemistry staining method A Phase II Study of Tegafur/Uracil (UFUR®)Plus Thalidomide for the Treatment of Advanced or Metastatic Hepatocellular Carcinoma (HCC) Condition: Carcinoma, Hepatocellular Intervention: Drug: Thalidomide(THADO), Tegafur/Uracil(UFUR) Is it Possible to Treat Cyanide Poisoning With HBO? Condition: Carbon Monoxide Poisoning From Fire Accidents Intervention: Procedure: HBO - hyperbaric oxygen treatment Rituximab, Fludarabine, Cyclophosphamide, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed B-Cell Non-Hodgkin's Lymphoma Condition: Lymphoma Interventions: Biological: rituximab; Drug: cyclophosphamide; Drug: fludarabine phosphate; Radiation: yttrium Y 90 ibritumomab tiuxetan Melanoma Inhibitory Activity (MIA): A Serological Marker for Metastatic Uveal Melanoma Conditions: Melanoma; Radiotherapy; Metastatic Disease Intervention: Procedure: Treatment of metastatic disease Mechanism and Prevention of Remote Organ Injury Following Ruptured Aortic Aneurysm Condition: Abdominal Aortic Aneurysm Intervention: Use of Hair to Diagnose the Presence of Breast Cancer Condition: Breast Cancer Intervention: Procedure: diagnosis of breast cancer by x-ray diffraction of hair Comparing Behavioral Therapies for Treating Adolescents With Post-Traumatic Stress Disorder Related to Sexual Abuse Condition: Post-Traumatic Stress Disorder Interventions: Behavioral: Prolonged exposure (PE) therapy for adolescents; Behavioral: Client centered therapy (CCT) Anti-Aggregative Therapy and Laser Iridectomy Condition: Eyes With Narrow Angle Intervention: Drug: The cessation of anti-aggregative treatment for 10 days Induction of Ovulation With Raloxifene or Clomiphene Citrate in Polycystic Ovarian Syndrome Condition: Polycystic Ovary Syndrome Interventions: Drug: clomiphene citrate; Drug: raloxifene Perinatal Hypothermia, Risk Factors and Long-Term Consequences in Guinea-Bissau, Westafrica Conditions: Hypothermia; Morbidity; Mortality Intervention: Device: thermospot The Validity of Retinal Blood Flow Measurements During Hyperoxia in Humans Using Fourier Domain Color Doppler Optical Coherence Tomography (CDOCT) Condition: Healthy Intervention: Other: 100% Oxygen
Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis Condition: Multiple Sclerosis Intervention: Anxiety Self-Management for ICU Patients Receiving Mechanical Ventilation Conditions: Anxiety; Mechanical Ventilation; Respiratory Conditions Such as Pneumonia or COPD Interventions: Behavioral: Anxiety Self-Management, Patient preferred relaxing music; Behavioral: Control 1: Noise-cancelling headphones; Behavioral: Control 2: Usual Care Pharmacokinetic of Ceftriaxone in Septic ICU Patients Conditions: Sepsis; Severe Sepsis; Septic Shock Intervention: Drug: ceftriaxone Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram Condition: Chagas Disease Intervention: Procedure: Trypanosoma cruzi serology Pharmacokinetic Evaluation of Moxifloxacin IV to Enteral Switch Therapy in Intensive Care Patients Condition: Pneumonia Intervention: Drug: IV and enteral administration of moxifloxacin Near-Infrared Spectroscopy (NIRS) Neurodevelopmental Outcomes Condition: Hypoplastic Left Heart Syndrome Intervention: Effect of S-adenosylmethionine (SAMe) on Blood Levels of Homocysteine Condition: Hyperhomocysteinemia Intervention: Dietary Supplement: S-adenosylmethionine Inflammatory Breast Cancer (IBC) Registry Condition: Breast Cancer Interventions: Other: Interview; Procedure: Blood and Tissue Collection Awareness of Deficit After Combat-related Brain Injury Conditions: Traumatic Brain Injury; Veterans Intervention: Collection of Samples and Data for the National Marrow Donor Program Repository Condition: Hematopoietic Stem Cell Transplantation Intervention: Somatosensory Evoked Potentials and Pain Thresholds in Term and Preterm-Born Adolescents After Early Exposure to Pain; a Quantitative Study Condition: Somatosensory Disorders Intervention: Device: Thermal stimulation Epidural Analgesia (EDA) Versus Patient Controlled Analgesia (PCA) in Laparoscopic Colon Surgery Condition: Laparoscopic Colectomy Interventions: Procedure: Epidural analgesia; Procedure: Patient controlled analgesia Postoperative Cognitive Dysfunction in Geriatric Patients Conditions: Delirium, Dementia, Amnestic, Cognitive Disorders; Age; Postoperative Complications; Memory Disorders Intervention: Home Blood Pressure Monitoring Trial Conditions: Stroke; Ischemic Attack, Transient Interventions: Behavioral: Intervention - a validated home BP monitor and support from the specialist nurse; Behavioral: Control - usual care (BP monitoring by their practice) Effect of Passive Gait Training on the Cortical Activity in Patients With Severe Brain Injury. Conditions: Craniocerebral Trauma; Traumatic Brain Injury; Subarachnoid Hemorrhage; Anoxic Brain Injury Intervention: Behavioral: Tilt Table With Integrated Stepping System p53-Adjusted Neoadjuvant Chemotherapy for Potentially Resectable Esophageal Cancer Condition: Esophageal Cancer Interventions: Drug: 5-Fluoruracil, Cisplatinum; Drug: Docetaxel Effects of Bariatric Surgery on Insulin Conditions: Obesity; Bariatric Surgery; Gastric Bypass; Weight Loss; Hyperglycemia Intervention: Chronic Obstructive Pulmonary Disease (COPD) Nutrition Support Trial Condition: Malnutrition Interventions: Dietary Supplement: Oral Nutritional Supplements (Fortisip); Other: Dietary Advice PCMRI - an MRI/TRUS System for the Evaluation of the Prostate Condition: Prostate Cancer Intervention: Device: PCMRI Bevacizumab in Treating Patients Who Have Undergone First-Line Therapy for Metastatic Colorectal Cancer Condition: Colorectal Cancer Interventions: Biological: bevacizumab; Procedure: adjuvant therapy
Treatment of Menorrhagia in Women With Thrombocytopenia: Comparison of Platelet Transfusion Alone to Platelet Transfusion With Continuous Oral Contraceptive Pills Conditions: Aplastic Anemia; Menorrhagia; Amenorrhea Intervention: Drug: Lo-Ovral Oral Contraceptive Pills MINIALO-VELCADE2005: A Study of Bortezomib (Velcade) Treated Multiple Myeloma Patients Pre and Post Allogeneic Haematopoietic Progenitor Cell Transplant With no Myeloablative Conditioning Condition: Multiple Myeloma Interventions: Drug: Bortezomib; Drug: dexamethasone; Drug: Fludarabine; Drug: Melphalan Effect of Pressure Support Ventilation and Neurally Adjusted Ventilatory Assist (NAVA) in Chronic Obstructive Pulmonary Disease (COPD) Patients Condition: Chronic Obstructive Pulmonary Disease Intervention: Procedure: PSV and NAVA Erlotinib in Treating Patients With Barrett Esophagus Conditions: Esophageal Cancer; Precancerous Condition Interventions: Drug: erlotinib hydrochloride; Other: laboratory biomarker analysis; Procedure: biopsy Safety Study of GlaxoSmithKline (GSK) Biologicals' Human Papillomavirus (HPV) Vaccine in Healthy Vietnamese Women According to a 0, 1, 6 Month Schedule Condition: Human Papillomavirus (HPV) Vaccine Intervention: Biological: HPV-16/18 L1 VLP AS04 vaccine Safety of Driving After Minor Surgery With Monitored Anesthesia Care Conditions: Minor Surgical Procedures With Monitored Anesthesia Care.; Driving Performance After Minor Ambulatory Surgery. Interventions: Other: Control; Drug: Midazolam; Drug: Sufentanil; Drug: Propofol Fertility Preservation by Ovarian and Oocyte Cryopreservation Conditions: Female Patients Aged 5-35 Prior to Systemic Chemotherapy; With Significant Risk of Ovarian Toxicity Intervention: Procedure: ovarian transplantation Biomarkers in Phototherapy of Barrett's Esophagus Conditions: Barrett's Esophagus; High Grade Dysplasia Interventions: Procedure: Photodynamic therapy; Procedure: radiofrequency ablation of barrett's esophagus Capsule Endoscopy Crohn's Disease Activity Index - Validation Multi Center Study Condition: Crohn's Disease Intervention: Device: Capsule endoscopy Quality of Life and Pain Outcomes Following Video-Assisted Thoracic Surgery (VATS) Anatomic Lung Resection Versus Thoracotomy and Anatomic Lung Resection Conditions: Lung Cancer; Quality of Life; Video-assisted Thoracic Surgery (VATS); Thoracotomy Intervention: Behavioral: questionnaires Effect of Large Volume Paracentesis on Fatigue in Cirrhosis Conditions: Ascites; Fatigue; Cirrhosis Intervention: Tamoxifen or Letrozole With or Without Bevacizumab in Treating Women With Stage III or Stage IV Breast Cancer Condition: Breast Cancer Interventions: Biological: bevacizumab; Drug: letrozole; Drug: tamoxifen citrate Phase III Study With Teriflunomide Versus Placebo in Patients With First Clinical Symptom of Multiple Sclerosis Condition: Multiple Sclerosis Interventions: Drug: Teriflunomide (HMR1726); Drug: Placebo Ziprasidone in the Psychosis Prodrome Condition: Psychosis Prodrome Interventions: Drug: ziprasidone; Drug: placebo Platelet Function Testing Help and Intraoperative Bleeding Risk for Patients Who Are on Plavix Prior to Surgery Condition: Perioperative Bleeding Intervention: Impact on Reducing the Incidence of Low Serum Calcium by Providing Educational Materials on the Need to Take Daily Supplemental Calcium and Vitamin D to Patients With Paget's Disease Treated With Reclast® Conditions: Paget's Disease of the Bone; Hypocalcemia Intervention: Drug: Reclast® Study of Brain Function in Women With Insulin Resistant Polycystic Ovary Syndrome Condition: Polycystic Ovary Syndrome Intervention: Drug: Metformin Study of Provider Computer Alerts Designed to Improve Delivery of HIV Care Condition: HIV Infections Interventions: Other: Provider Computer Alerts; Other: Enhanced Provider Computer Alerts Evaluating the Effectiveness of Meditation in Lowering Blood Pressure in African Americans (The HMEC Study) Condition: Hypertension Interventions: Behavioral: Transcendental Meditation program; Behavioral: Enhanced health education program Raltegravir And Darunavir Antiretroviral in Antiretroviral Naive Patients Condition: HIV Infections Interventions: Drug: Raltegravir; Drug: Darunavir; Drug: Ritonavir; Drug: Tenofovir/Emtricitabine
Calfactant for Direct Acute Respiratory Distress Syndrome Condition: Respiratory Distress Syndrome, Adult Interventions: Drug: Calfactant; Drug: Room Air (placebo) A German Multicenter Study on Toxoplasma Gondii in First-episode Schizophrenia Conditions: Schizophrenia; Schizophreniform Disorder; Schizoaffective Disorder Intervention: Other: TAU = treatment as usual Docetaxel Plus Oxaliplatin as Therapy in Patients With Pancreatic Cancer Condition: Pancreas Neoplasms Interventions: Drug: Docetaxel; Drug: Oxaliplatin Safety Study Involving Oxaliplatin With Docetaxel for Recurrent Ovarian,Primary Peritoneal, and Fallopian Tube Cancer Conditions: Ovarian Cancer; Peritoneal Cancer; Fallopian Tube Cancer Interventions: Drug: intravenous docetaxel with intraperitoneal oxaliplatin; Drug: intravenous oxaliplatin with intraperitoneal docetaxel Varenicline to Reduce Alcohol Consumption in Heavy Drinkers Condition: Alcohol Drinking Interventions: Drug: Varenicline; Drug: Varenicline (Chantix) Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers Condition: Tobacco Use Disorder Intervention: Other: Product Preference Oral Versus Intravenous Rehydration for Prevention of Dehydration in Premature Babies, During the First Days of Life. Conditions: Low Birth Weight Infant; Enteral Nutrition Interventions: Procedure: Oral rehydration therapy; Procedure: classical hydration via intravenous infusion High Density Lipoprotein (HDL) Functionality in Metabolic Syndrome Condition: Metabolic Syndrome X Intervention: ICU Family Communication Study Conditions: Depression; Depressive Symptoms; Anxiety; Stress Disorders, Post-Traumatic; ICU Hospitalization; Care and Treatment in ICU Interventions: Behavioral: Facilitator-Based intervention; Behavioral: Usual Care Pharmacogenetic Study for Topiramate-Induced Cognitive Dysfunction Condition: Cognitive Dysfunction Intervention: Telephone Support for Dementia Caregivers Condition: Dementia Interventions: Behavioral: Family Intervention:Telephone Tracking Support- Caregiver; Behavioral: Telephone Support Cervical Stairstep and Effects on Range of Motion (ROM) Condition: Range of Motion, Articular Intervention: Procedure: Cervical Stairstep Ultrasound Evaluation of the Rotator Cable and Associated Structures. Condition: Shoulder Pain Intervention: Other: ultrasound Resistance Exercise Training For Radically Treated Respiratory Cancer Condition: Respiratory Cancer Interventions: Other: Control group; Other: Conventional resistance training; Other: Whole body vibration resistance training A Multi-site Randomized Controlled Trial Comparing Regional and General Anesthesia for Effects on Neurodevelopmental Outcome and Apnea in Infants Condition: Inguinal Hernia Interventions: Drug: Regional Anesthesia; Drug: General Anesthesia Surveillance of Influenza Virus Among Children With Febrile Respiratory Complaints Attending the Pediatric Clinic of the First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, Mainland China Conditions: Influenza Type A; Influenza Type B Intervention: Procedure: Nasopharyngeal Swab Treatment for Word Retrieval Impairments in Aphasia Condition: Stroke Intervention: Behavioral: Word Retrieval Treatments for Aphasia A Randomized Phase II Study of Itraconazole and Pemetrexed in Patients With Previously Treated Non-Squamous Non-Small Cell Lung Cancer Condition: Recurrent Non Small Cell Lung Cancer Intervention: Drug: Itraconazole Neuropsychological and Behavioral Testing in Young Patients With Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor (PNET) Conditions: Brain and Central Nervous System Tumors; Chemotherapeutic Agent Toxicity; Cognitive/Functional Effects; Neurotoxicity; Psychosocial Effects of Cancer and Its Treatment; Radiation Toxicity; Therapy-related Toxicity Interventions: Other: questionnaire administration; Procedure: cognitive assessment; Procedure: psychosocial assessment and care; Procedure: quality-of-life assessment Telehealth Evaluation Conditions: Congestive Heart Failure; Chronic Obstructive Pulmonary Disease Intervention:
An Open Label Pharmacokinetic, Safety And Efficacy Study Of Maraviroc In Combination With Background Therapy For The Treatment Of HIV-1 Infected, CCR5 -Tropic Children Condition: Human Immunodeficiency Virus (HIV) Intervention: Drug: Maraviroc Community Based Exercise Program for Well Cancer Survivors Condition: Cancer Intervention: Other: Exercise program Bacterial Vaginosis in Pregnancy: Detection by Weekly Vaginal pH Testing Conditions: Pregnancy; Bacterial Vaginosis; Preterm Delivery Intervention: Other: Screening Computed Tomography (CT) - Guided Brachytherapy Versus Transarterial Chemoembolization in Patients With Unresectable Hepatocellular Carcinoma Condition: Hepatocellular Carcinoma Interventions: Radiation: CT-guided brachytherapy; Procedure: transarterial chemoembolization Treatment Of Radiation Retinopathy Trial Condition: Uveal Melanoma Interventions: Drug: ranibizumab; Drug: triamcinolone acetonide; Other: sham Empowerment of Lung and Heart-lung Transplant Patients Conditions: Lung Transplantation; Heart-Lung Transplantation; "Rehabilitation"; Psychotherapy; Exercise Training Interventions: Behavioral: resource-activating behavioural training programme; Behavioral: Relaxation training; Behavioral: Intensified anaerobic exercise training; Behavioral: Moderate aerobic exercise training Effects of the Ivabradine on Reduction of Inflammatory Markers in Patients With Acute Coronary Syndrome Condition: Acute Coronary Syndromes Interventions: Drug: Ivabradine; Drug: Placebo Progesterone for the Treatment of Traumatic Brain Injury Condition: Traumatic Brain Injury Intervention: Drug: Progesterone Behavior and Exercise Versus Drug Treatment in Men With Nocturia (BEDTiMe) Condition: Nocturia Interventions: Behavioral: Behavioral; Drug: tamsulosin (alpha-adrenergic antagonist medication); Drug: placebo; Behavioral: placebo Cognitive Training to Enhance VA Work Program Outcomes Conditions: Mental Illness; Schizophrenia; Depression; PTSD; Bipolar Disorder Interventions: Behavioral: Cognitive Remediation; Behavioral: Nintendo Brain Age Children's Attention Deficit Disorder With Hyperactivity (ADHD) Telemental Health Treatment Study Condition: Attention Deficit Disorder With Hyperactivity Intervention: Other: CATMH intervention Haloperidol vs Olanzapine for the Management of ICU Delirium Conditions: Delirium; Agitation Interventions: Drug: Haloperidol; Drug: Olanzapine Renin Profiling in Selection of Initial Antihypertensive Drug Condition: Hypertension Interventions: Drug: Olmesartan, hydrochlorothiazide, amlodopine; Drug: Hydrochlorothiazide (HCTZ) or Olmesartan Oncaspar/Doxil/Decadron in Patients With Refractory Lymphoid Malignancies Conditions: Non-hodgkins Lymphoma; Hodgkins Lymphoma; Multiple Myeloma Intervention: Drug: Oncaspar, Doxil, Decadron Kuvan Therapy in Phenylketonuria (PKU): The Effect of Blood Phenylalanine Concentration on Kuvan Response Condition: Phenylketonuria Intervention: Drug: Kuvan Proton Therapy for Hodgkin Lymphoma Condition: Hodgkin Lymphoma Interventions: Radiation: Proton Therapy; Radiation: Conventional AP/PA; Radiation: IMRT Glucagon-Like Peptide 1 (GLP-1) and Endothelial Dysfunction in Metabolic Syndrome Condition: Metabolic Syndrome Intervention: Drug: GLP-1 infusion MAP-IDM: Identification of Molecular Markers of Sudden Death at the Acute Phase of Myocardial Infarction Condition: Myocardial Infarction Intervention: Genetic: Blood sample Safety and Efficacy Study of PG2 to Treat Idiopathic Thrombocytopenic Purpura (ITP) Patients Condition: Idiopathic Thrombocytopenic Purpura (ITP) Intervention: Drug: PG2 Asthma Learning Project Condition: Asthma Interventions: Other: Educational game; Other: Educational game + motivational interview; Other: Motivational interview
Study of PXD101 and Doxorubicin to Treat Soft Tissue Sarcomas Condition: Soft Tissue Sarcomas Intervention: Drug: PXD101 + doxorubicin Randomized Study of Ixabepilone Versus Observation in Patients With Significant Residual Disease Condition: Breast Cancer Intervention: Drug: Ixabepilone Efficacy of Minoxidil in Children With Williams-Beuren Syndrome Condition: Williams Beuren Syndrome Interventions: Drug: Minoxidil; Drug: Placebo Internet-based Intervention in Cardioverter-defibrillator Patients to Enhance Quality of Life Conditions: Heart Diseases; Implantable Cardioverter-Defibrillators Intervention: Behavioral: web-based multifactorial intervention Prevalence of Atrial Delay That Would Preclude Optimization of Atrioventricular (AV) Delay in Patients With Biventricular (BiV) Device Condition: Heart Failure Intervention: Left Atrial Appendage Occlusion Study II Conditions: Atrial Fibrillation; Stroke Interventions: Procedure: Surgical occlusion of the left atrial appendage; Procedure: Best medical practice Vorinostat, Carboplatin and Gemcitabine Plus Vorinostat Maintenance in Women With Recurrent, Platinum-Sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer Conditions: Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cavity Cancer Interventions: Drug: Vorinostat; Device: Carboplatin; Drug: Gemcitabine Safety Study of Adult Stem Cells to Treat Patients With Severe Leg Artery Disease Conditions: Critical Limb Ischemia; Arterial Occlusive Disease; Vascular Diseases Intervention: Biological: autologous CD133+ cells Comparison of the HyperQ Versus Conventional Electrocardiogram (ECG) to Detect Ischemia Condition: Coronary Artery Disease Intervention: N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy Conditions: Diabetic Nephropathies; Proteinuria; Oxidative Stress Interventions: Dietary Supplement: N-acetylcysteine; Dietary Supplement: silibin; Dietary Supplement: high-dose silibin; Dietary Supplement: N-acetylcysteine placebo; Dietary Supplement: silibin placebo Herb Drug Interaction of Traditional Chinese Herb and Commonly Used Drugs Condition: Healthy Interventions: Drug: Nalbuphine; Drug: Morphine; Drug: Morphine with Long dan xie gan tang; Drug: Nalbuphine with Long dan xie gan tang; Drug: Nubian with Long dan xie gan tang Study to Test the Usefulness of Magnetoencephalography (MEG) Imaging of Cognition in Children and Adolescents Condition: Cognition Intervention: Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination Condition: Pain, Postoperative Interventions: Drug: Ibuprofen + Paracetamol; Drug: Ibuprofen + Paracetamol + Codeine; Drug: Paracetamol + Codeine; Drug: Placebo The Role of the Glutamatergic System in the Extinction of Conditioned Reinforcement Processes Condition: Alcohol Drinking Interventions: Drug: D-cycloserine; Drug: Placebo A Study to Evaluate New or Worsening Lens Opacifications in Subjects With Non-metastatic Prostate Cancer Receiving Denosumab for Bone Loss Due to Androgen-Deprivation Therapy Conditions: Cancer; Cataract; Low Bone Mineral Density; Osteopenia; Osteoporosis; Prostate Cancer Interventions: Biological: Denosumab; Biological: Placebo Antioxidant Replacement Therapy in Patients With Alcohol Abuse Condition: Alcohol Abuse Intervention: Dietary Supplement: Protandim Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia Condition: Hypoxic Ischaemic Encephalopathy Intervention: Other: Xenon gas Pharmacogenetic DNA Bank Condition: Cancer Intervention: Biological: Blood collection CT Coronary Angiogram Versus Traditional Care in Emergency Department Assessment of Potential ACS Conditions: Chest Pain; Acute Coronary Syndrome; Acute Myocardial Infarction; Coronary Artery Disease Interventions: Procedure: CT Coronary Angiography; Procedure: Traditional, Standard of Care Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head Condition: Avascular Necrosis of Femoral Head Intervention: Drug: zoledronic acid (aclasta)
Validating 4Ts for Heparin Induced Thrombocytopenia (HIT) Condition: Heparin-Induced Thrombocytopenia Interventions: Other: Scoring 4Ts and Chong scale; Other: Blood draw Combined Haploidentical-Cord Blood Transplantation for Adults and Children Conditions: Leukemia; Myelodysplastic Syndrome; Multiple Myeloma; Lymphoma Interventions: Drug: Fludarabine-Melphalan & Rabbit antithymocyte globulin; Procedure: Stem Cell Transplant; Procedure: Stem Cells Collections Effects of Postconditioning On Myocardial Reperfusion Conditions: Myocardial Reperfusion; Myocardial Infarction Intervention: Procedure: Post-conditioning Increasing Patching for Amblyopia in Children 3 to < 8 Years Old Condition: Amblyopia Intervention: Device: Eye Patch Early Connections, Early Detection and Intervention in Infants at Risk for Autism Condition: Autism Spectrum Disorder Interventions: Behavioral: Assessment & Monitoring; Behavioral: Assessment, Monitoring & Intervention Ibuprofen as a Possible Preventer of Post Bronchoscopy Fever Condition: Post Bronchoscopy Fever Intervention: Drug: ibuprofen An Implementation and Biobehavioral Study of Temporomandibular Joint and Muscle Disorder (TMJMD) Condition: Temporomandibular Joint and Muscle Disorder Interventions: Behavioral: Biobehavioral; Behavioral: Active Coping/Attention Intervention Raltegravir Switch for Toxicity or Adverse Events Conditions: HIV/AIDS; Antiretroviral Therapy; HIV Infections Interventions: Drug: tenofovir emtricitabine raltegravir; Drug: Lamivudine Abacavir Raltegravir; Drug: Abacavir free MRI in Assessing Hypoxia in Patients With Localized Prostate Cancer Undergoing Stereotactic Body Radiation Therapy Condition: Prostate Cancer Interventions: Procedure: blood-oxygen-level-dependent functional magnetic resonance imaging; Procedure: dynamic contrast-enhanced magnetic resonance imaging; Procedure: magnetic resonance spectroscopic imaging; Procedure: tissue-oxygen-level-dependent functional magnetic resonance imaging Bilateral Transversus Abdominis Plane Block and Postoperative Pain Intensity After Elective Cesarean Delivery Condition: Postoperative Pain Intervention: Procedure: TAP blockade Study of Tissue Samples From Patients With Glioma or Other Brain Tumors Condition: Brain and Central Nervous System Tumors Interventions: Other: laboratory biomarker analysis; Other: pharmacogenomic studies Endoscopic Band Ligation (EBL) Versus Propranolol for Primary Prophylaxis of Variceal Bleeding Conditions: Variceal Bleeding; Cirrhosis Interventions: Procedure: Endoscopic band ligation; Drug: Propranolol; Procedure: endoscopic band ligation and propranolol Understanding the Psychosocial Needs of Parents Who Have Lost a Child to Cancer Condition: Parents Who Have Lost a Child to Cancer Intervention: Behavioral: Questionnaires/Interviews Fatigue in Breast Cancer Survivors Conditions: Breast Cancer; Cancer Survivor; Fatigue; Psychosocial Effects of Cancer and Its Treatment Interventions: Genetic: protein analysis; Other: laboratory biomarker analysis; Other: mass spectrometry; Other: questionnaire administration; Procedure: assessment of therapy complications; Procedure: cognitive assessment; Procedure: quality-of-life assessment Treatment of Autonomous Hyperparathyroidism in Post Renal Transplant Recipients Conditions: Chronic Allograft Nephropathy; Chronic Kidney Disease; Chronic Renal Failure; Disordered Mineral Metabolism; End Stage Renal Disease; Hyperparathyroidism; Hypophosphatemia; Kidney Disease; Kidney Transplantation; Post Renal Transplantation Interventions: Drug: Cinacalcet; Drug: Placebo Doctor-Recommended Home-Based Exercise Program or Relaxation Training in Improving Physical Function and Controlling Symptoms in Patients With Stage IV or Recurrent Colon Cancer That Cannot Be Removed By Surgery Condition: Colorectal Cancer Interventions: Behavioral: exercise intervention; Behavioral: telephone-based intervention; Other: counseling intervention; Other: questionnaire administration; Other: survey administration; Procedure: management of therapy complications; Procedure: mind-body intervention procedure; Procedure: quality-of-life assessment; Procedure: stress management therapy Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Cholecystectomy Conditions: Cholelithiasis; Biliary Dyskinesia Intervention: Procedure: NOTES Transvaginal Cholecystectomy The Effect of Late Night Meals on Fasting Glucose in Type 2 Diabetes Patients Condition: Fasting Hyperglycemia Intervention: Dietary Supplement: late night meal Glucose Homeostasis Pre and Post Bariatric Surgery Condition: Morbid Obesity Interventions: Procedure: gastric bypass; Procedure: gastric banding Study to Assess Airway Inflammation Effects of FlutiForm® pMDI Low and High Dose in Adults With Mild to Moderate Asthma Condition: Asthma Intervention: Drug: Fluticasone propionate / Formoterol fumarate
Treatment of Depression in Acute Coronary Syndrome (ACS) Patients Condition: Depression Intervention: Behavioral: CBT in combination with WBT and life style modification Colour Coded Duplex Ultrasound of Native Arterio-venous Fistula for Haemodialysis With Venous Pressure Measurement Using Controlled Compression Ultrasound as a Predictor for Shunt Maturation in the Early Postoperative Phase Condition: Renal Insufficiency Intervention: Procedure: Ultrasound (Pressure measurement) Induction Chemotherapy Followed by Cetuximab Plus Definitive Radiotherapy Versus Radiation Plus Cisplatin Condition: Squamous Cell Carcinoma of the Head and Neck Interventions: Drug: docetaxel - cisplatin - 5-fluorouracil; Radiation: radiotherapy; Drug: cetuximab; Drug: cisplatin Intraocular Pressure (IOP) Lowering Effect of Selective Laser Trabeculoplasty Versus Prostaglandin Analogues in Angle Closure Glaucoma Condition: Glaucoma Interventions: Procedure: Selective Laser Trabeculoplasty; Drug: Travoprost/ Timolol/ Azopt/ Brimonidine Ultrasonic Measurements of the Clitoris in Fetuses Condition: Ambiguous Genitalia Intervention: A Randomized Clinical Trial for Toddlers With ASD Condition: Autism Spectrum Disorder Interventions: Behavioral: Social Communication; Behavioral: Social communication Comparative Study to Examine Whether Echocardiography Performed During Cardiac Resynchronization Therapy Device Implantation Can Improve the Response Rate Conditions: Heart Failure; Cardiac Resynchronization Therapy; Echocardiography Interventions: Device: Empirical group; Device: Echocardiography-guided approach Modulation of the Immune Response in Patients With Pancreatic Tubular Adenocarcinoma Condition: Pancreatic Tubular Adenocarcinoma Intervention: Biological: MIS Serum Lipid Levels and Other Biomarkers of Cardiovascular Disease in Patients With Psoriasis Conditions: Psoriasis; Cardiovascular Diseases; Dyslipidemia Intervention: Azacitidine and Lenalidomide for Acute Myeloid Leukemia Condition: Leukemia, Myeloid, Acute Intervention: Drug: Azacitidine and Lenalidomide Surgery or Capsular Distention With Steroid in the Treatment of Primary Frozen Shoulder? Condition: Adhesive Capsulitis Interventions: Procedure: Arthroscopic capsular release; Procedure: Distention with steroid Phase II Trial of Alemtuzumab (Campath) and Dose-Adjusted EPOCH-Rituximab (DA-EPOCH-R) in Relapsed or Refractory Diffuse Large B-Cell and Hodgkin Lymphomas Conditions: Hodgkin Lymphoma; Diffuse Large B-Cell Lymphoma Interventions: Drug: Cylcophosphamide; Drug: Etoposide; Drug: Alemtuzumab; Drug: Doxorubicin; Drug: Prednisone; Drug: Filgrastim; Drug: Rituximab; Drug: Vincristine Biochemical Approach to Measuring Surgical Trauma Condition: Total Knee Replacement Intervention: Donor Stem Cell Transplant in Treating Patients With High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Conditions: Leukemia; Lymphoma Interventions: Biological: anti-thymocyte globulin; Biological: rituximab; Drug: busulfan; Drug: cyclophosphamide; Drug: fludarabine phosphate; Drug: methotrexate; Drug: sirolimus; Drug: tacrolimus; Other: laboratory biomarker analysis; Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation; Procedure: peripheral blood stem cell transplantation Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Conditions: Brain and Central Nervous System Tumors; Cognitive/Functional Effects; Fatigue Interventions: Drug: armodafinil; Other: placebo Calcineurin Inhibitor-free, Steroid-free Immunosuppressive Regimen in Simultaneous Islet-Kidney Transplantation for Uremic Type 1 Diabetic Patients Conditions: Islets of Langerhans Transplantation; Diabetes Mellitus, Type 1; Kidney Transplantation Intervention: Drug: Belatacept Circulating Endothelial Compartment During Normal and Pathological Aging Condition: Healthy Intervention: Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation Condition: Respiratory Distress Syndrome, Newborn Interventions: Device: Endotracheal tube insertion; Device: Laryngeal mask airway insertion Safety Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer Conditions: Metastatic Pancreatic Cancer; Metastatic Colorectal Cancer Intervention: Drug: NPC-1C CYP2D6 Screening for Adverse Drug Reactions to Codeine in Breast Milk Condition: Cytochrome P450 2D6 Ultra-rapid Metabolism Intervention: Genetic: Cytochrome P450 2D6 (CYP2D6) genetic screening.